Funded Projects

 

TechAdvance®

Platform Technology for Native Free Radical-Initiated Targeting and Immobilization of Therapeutics

Rutgers Inventor(s): David Shreiber
Awarded: May 2018

Summary:

A platform approach that aims to harness the reactivity of free radicals associated with various pathological states to target and sustain the delivery of therapeutics at the disease site using acrylated PEG. The project will characterize additional biodegradable materials for their capacity in mediating targeted delivery and perform efficacy testing in rodent models

Market Applications:

  • Targeted delivery of bioactive materials such as therapeutics, trophic factors and micronutrients
  • Free radical scavenger – prevention of secondary injury
  • Applicable to a variety of diseases associated with elevated level of free radicals
  • Imaging/detection of early stage diseases

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Targeted Delivery of Vitamin E Acetate to Skin using Rutgers TyroSpheres

Rutgers Inventor(s): Joachim Kohn
Awarded: April 2018

Summary:

Rutgers has developed a self-assembling polymer that is biodegradable, called TyroSpheres, which can be formulated to carry Vitamin E to the skin surface as well as intradermal as part of a cosmetic product.  A unique collaboration with Colgate, TryroSpheres formulated with Vietnam E will be synthesized, studies with a cadaver skin model will be formed which directly compare the TryoSpheres formulation with two competitive Colgate formulations as controls. Full mass balance and confocal laser scanning microscopy will be used to quantify the delivery of Vitamin E in the different skin layers.

Biopharmaceutical Manufacturing Using Bioactive Cell Growth Capsules

Rutgers Inventor(s): Biju Parekkadan
Awarded: March 2018

Summary:

Dr. Parekkadan designed a bioactive polymer technology that shields cells as they grow within mechanical durable capsules. These capsules can be dissolved after culturing is complete to efficiently recover the cell or biomolecular product. 

Diagnostic Application for Schizophrenia and Mental Disorders

Rutgers Inventor(s): Thomas Papathomas
Awarded: February 2018

Summary:

An objective and widely accessible assessment tool to help diagnose or assess treatment successes in real time in Schizophrenia patients. Software/app is being developed to measure the visual perception of the hollow-mask illusion, which is an evidence-based indication of degree of Schizophrenia manic state. 

Development of a Broad-Spectrum Antifungal Vaccine

Rutgers Inventor(s): Chaoyang Xue
Awarded: February 2018

Summary:

Dr. Xue's vaccine fills the current drug gap for invasive fungal infections with a novel broad-spectrum human vaccine against disease causing fungal pathogens such as Cryptococcus and Aspergillus species that often causes lung and brain infection in immunocompromised patients, with a high fatality rate.  The therapy will be explored using a proprietary heat-killed mutant fungal strain. 

Market Applications:

  • Vaccine (whole cell, heat-killed)
  • Vaccine adjuvant to prevent and treat fungal infection

Biomimetic, Bioactive Dental Implants

Rutgers Inventor(s): Amir Fakhrzadeh; Rafael Benoliel
Awarded: February 2018

Summary:

This project aims to solve common issues and limitations with titanium dental implants by designing a customizable biomimetic implant. Using a bioactivecomposite material, dental implants are derived from the patient’s own extracted tooth material. 

Market Applications:

  • Transitional dental implants
  • Long term dental implants
  • Dental implants in children and young adult
  • Inexpensive materials and equipment
  • Chair-side fabrication
  • Rapid set time (12 minutes)
  • Compressive strength exceeds masticatory (bite) forces
  • Patient-specific geometry
  • Integration of bioactive composite with jaw

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A Novel Composition & Method for Treating Neuropsychiatric Disorders

Rutgers Inventor(s): Gary Aston-Jones ; Hannah Bowrey
Awarded: January 2018

Summary:

Targeting retinal ganglion cells Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) introduces a gene therapy treatment for neuropsychiatric disorders including depression. When the DREADDS are activated by generic eye drops, these cells modulate the brain’s natural pathways reducing the symptoms of depression in animal models. This therapy has the potential to treat many neuropsychiatric disorders without systemic exposure to neuropsychiatric drugs with high side-effects. | Pharmaceutical gene therapy – neuropsychiatric disorders

Market Applications:

  • Agents and method for therapeutic treatment of neuropsychiatric disorders, such as depression and circadian disorders.
  • A kit for therapeutic treatment of depression.

Download: PDF icon Technology Details (pdf)

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Clinical Validation of FISH Assay for Early Detection of Esophageal Cancer

Rutgers Inventor(s): Manisha Bajpai; Kiron M. Das; Hana Aviv
Awarded: December 2017

Summary: Objective minimally invasive (small biopsy sample) diagnostic of the risk of forming esophageal adenocarcinoma (EA cancer) in patients with Barrett’s epithelium (BE). Specific cancer causing chromosomal abnormalities are identified using specially design chromosomal regional probes (FISH probe).

Market Applications:

  • Objective test for cancer risk in BE patients
  • Can be combined with traditional pathology procedures
  • Early detection of cancer, allowing early intervention and expanding treatment options
  • Stratification of high-risk BE patients and early detection of esophageal adenocarcinoma

Download: PDF icon Technology Details (pdf)

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New Antibiotics: Efficient Microbial Extract Screening and Mutational De-Replication

Rutgers Inventor(s): Richard H. Ebright; Stefano Donadio
Awarded: December, 2017

Summary: This new platform technology overcomes two obstacles to discovering and prioritizing new antibacterial compounds by use of microbial-extract screening: (1) microbial extracts can contain previously known antibacterial compounds (resulting in effort wasted on re-isolation of previously known antibacterial compounds), and (2) microbial extracts can contain antibacterial compounds at concentrations that differ by multiple orders of magnitude (invalidating use of rankings of antibacterial activities of extracts to infer antibacterial activities of antibacterial compounds therein).

Market Applications: 

  • New antibacterial drug discovery platform.
  • Pipeline of new antibacterial lead compounds

Download: PDF icon Technology Details (pdf)

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Novel Biosensors for Rapid Determination of Antimicrobial Resistance (AMR)

Rutgers Inventor(s): Yicheng Lu; Pavel Ivanoff Reyes; Steven Zheng; Keyang Yang; Andrew Zheng
Awarded: July 2017

Summary: This project focuses on the development of a highly sensitive, dynamic, rapid, compact and low cost diagnostic sensor technology for monitoring antimicrobial resistance (AMR) and screening antimicrobials that work against resistant strains. This technology is well-suited for AMR detection and has shown the ability to detect the bactericidal effect of ampicillin in E. coli within 10 minutes. In addition, it is also able to detect the growth inhibition effect of miconazole and cytotoxic effect of amphotericin B in yeast within 20-40 minutes.

Market Applications:

  • AMR diagnostic tool/point-of-care diagnostics devices
  • Research assays
  • Drug discovery - high throughput screening of antibiotics, antifungal and anticancer agents

Download: PDF icon Technology Details (pdf)

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First-in-Class Pan-TAM Inhibitors for Cancer Therapy

Rutgers Inventor(s): William J. Welsh; Raymond Birge; Youyi Peng; Vladyslav Kholodovych; Stanley Kimani; Thomas W. Comollo
Awarded: June 2017

Summary: This project focuses on a novel family of small molecule inhibitors that uniquely block TAM receptors (Tyro3, Axl, and Mertk) activation by the endogenous ligand Gas6 in the extracellular domain. In vitro and in vivo tests have demonstrated good anti-cancer activities without discernible toxicity to normal cells/tissues.

Market Applications:

  • Anti-cancer therapeutic
  • Combined with other therapies such as PD-1 immune checkpoint inhibitors
  • Treatment of infectious diseases

Download: PDF icon Technology Details (pdf)

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A New Catalyst for Generation of Carbon Feedstocks & Fuels from Carbon Dioxide

Rutgers Inventor(s): G. Charles Dismukes; Martha Greenblatt; Anders Laursen; Karin Calvinho
Awarded: June 2017

Summary: This project focuses on transition metal phosphide catalysts used to selectively generate valuable hydrocarbons for fuel or chemical feedstocks for production from CO2. Using renewable electricity for power, the process can be fully sustainable and a carbon neutral technology.

Market Applications:

  • Renewable feedstocks and fuels
  • Methane and ethylene production for the chemical industry
  • CO2 gas to solids via polymeric [CH2O]n (3>n>100), CO2 emissions recycling/mitigation, electrical energy storage;

Download: PDF icon Technology Details (pdf)

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Tracking the Spread of Cancer with Light for Targeted Treatment

Rutgers Inventor(s): Prabhas Moghe; Richard Riman; Mei-Chee Tan; Dominik Naczynski
Awarded: June 2017

Summary: This project focuses on a new rare earth (RE)-based light-emitting, multifunctional composites for use in a wide variety of biomedical applications including the identification and tracking of cancer. They found that the properties of the composites, in particular their aqueous stability, solubility, biocompatibility, and functionality, can be tailored for specific applications by coating RE nanoparticles with suitable polypeptides, polysaccharides or polymers.

Market Applicaitons:

  • Non-invasive imaging (2 and 3-dimensional)
  • Image-guided interventions (surgical and non-surgical)
  • Drug tracking and delivery
  • Photodynamic therapy

Download: PDF icon Technology Details (pdf)

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Using Virtual Reality to Help Persons Walk Post Stroke

Rutgers Inventor(s): Judy Deutsch; Robb Gosine
Awarded: May 2017

Summary: This project focuses on a low cost and scalable solution for bringing virtual reality rehabilitation into clinics and patients' homes.

Market Applications:

  • Games were developed to be used at home by patients needing physical therapy
  • First in person with therapist, then can be moved entirely virtual
  • Data collected from the game can be shared with physicians and other therapists
  • Expectation is device and virtual sessions with a therapist will be covered or reimbursed by health insurance

Download: PDF icon Technology Details (pdf)

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High Performance Graphene-Polymer Matrix Composites

Rutgers Inventor(s): Jennifer Lynch; Tom Nosker; Bernie Kear
Awarded: April 2017

Summary: This project focuses on a scalable method to exfoliate graphite into graphene directly within a molten polymer. The discovery creates the opportunity for the development of lightweight, high performance, next generation materials of extraordinary strength and impact resistance.

Market Applications:

  • Military (lightweight armor, vehicles, small boats, helmets, munitions)
  • Aerospace (UAVs)
  • Transportation (vehicles, small boats)
  • Infrastructure (bridges)
  • Sporting Goods (tennis, golf, hockey, skiing)
  • Packaging (barrier resistant layer)
  • Feedstock for polymer industry

Download: PDF icon Technology Details (pdf)

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TechXpress

Sigma-1 Receptor (S1R) Antagonists as Alternatives to Opioid Narcotics for Treatment of Pain

Rutgers Inventor(s): Bill Welsh
Awarded: April 2018

Summary:

New discoveries have associated the Sigma-1 Receptor (S1R) in neurons with pain and a possible target for pain management. The June 2016 publication of the X-ray crystal-based 3D structure for the human S1R-antagonist structure, has allowed the computational design of novel S1R molecules with potential clinical use by this Rutgers team. A limited number of compounds have been designed and tested with promising potency, safety and other features. The project will fund the design and synthesis of more novel compounds and conduct in vitro S1R binding assay and potency determination. The top performing compounds will be combined with commonly used opioids in vivo to explore whether these compounds potentiates the opioids and/or mitigate sides effects.

Vector Development for Stem Cell Transfection

Rutgers Inventor(s): Arash Hatefi
Awarded: February 2018

Summary:

Dr. Hatefi developed a novel, safe, and highly efficient human stem cell transfection system (including novel vectors, buffer and other components). Key to the vectors properties is its ability to target the VEGFR-1 cell surface receptor which is expressed on adipose-derived stem cells and is predicted to be expressed other stem cell types of therapeutic interest. The project aims to confirm that the novel transfection system works for both bone marrow derived and neural stem cells

Market Applications:

  • Transfection reagent for stem cells for clinical and research applications

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In Vitro Generation of Antigen-Specific Memory T-cells

Rutgers Inventor(s): Fumio Matsumura
Awarded: January 2018

Summary:

Dr. Matsumura developed a novel method to generate antigen-specific memory T-cells in vitro with mouse dendritic cells that can target cancer cells expressing specific antigens. Key to this method is the optimization of the cell culture environment and process to maximize T-cell differentiation into memory T-cells and be harvested at a therapeutically significant quantity. The project will attempt to adopt the team’s current methodology into humans and generate human memory T-cells in vitro.

Scale-up and Mechanical Testing of Polymers made from Silica

Rutgers Inventor(s): Masanori Hara
Awarded: January 2018

Summary:

The technology is a family of polymers with inorganic backbones (Si-O and P-O) and ionic crosslinks (inorganic ionomers) that can be produced from minerals that are abundant in the earth’s crust. The strong inorganic backbone lead to high chemical and thermal stability, reducing the number of toxic byproducts. The ionic crosslinks are reversible, contributing to self-healing properties of the polymers. These inorganic ionomers may vary from soft rubbery materials, plastic like consistency, to hard resins, giving them a wide range of applications. Manufacture around 100 grams of the sample material, compare the material’s mechanical properties (impact strengths and tensile/compressive properties) to commercially relevant materials made of PS/PMMA

Market Applications:

  • Biocompatible food packaging
  • Flexible displays
  • Fuel cell membranes
  • Adhesives
  • Catalysts
  • Composites
  • Automotive

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Treatment of Fibrotic Diseases Using Agents that Disrupt the Structure of Collagen

Rutgers Inventor(s): Edward Yurkow
Awarded: November 2017

Summary:

Dr. Yurkow is exploring the use of a commonly available agent to reverse progression of diseases associated with collagen fibrosis such as Idiopathic Pulmonary Fibrosis(IPF) and liver cirrhosis. The target agent’s mechanism of action leads to a disruption of fibrous collagen to form secondary and tertiary structures.

Synthetic Antibody Production for Immunotherapies

Rutgers Inventor(s): William Belden
Awarded: October 2017

Summary:

A novel method to generate complex antibody phage display libraries. This method utilizes a recombination-based cloning method with a set of proprietary DNA plasmids, which allow for the recombination of any antibody light chain with any antibody heavy chain even across different species. The method also prevents the common toxic effects of single-chain variable fragments (scFv) to the yeast cells during the cloning process.  Use this method to construct a novel scFv library against triple-negative breast cancer cells consisting of 107-109 unique clones. Then screen the library to identify high-affinity scFv for the cancer cells.

3-D Pre-Vascularized Scaffold for Bone Regeneration

Rutgers Inventor(s): Joseph Freeman; Pankaj Pushpendra Patel
Awarded: June 2017

Summary: This project focuses on a novel bone graft which combines bone-like architecture, ceramic support structures, pre-vascularized tubes, and patient-derived stem cells to create a graft that can immediately support patient weight upon implantation and simultaneously develop new bone and integrated vasculature for short-term and long-term viability and mechanics.

Market Applications:

  • Treatment for bone disorder, loss, and skeletal deficiencies arising from traumatic injury, abnormal development, cancer, and degenerative bone diseases
  • The bone grafting market in the U.S. has an estimated value over $1 billion, making bone second to blood as the most frequently transplanted material
  • Currently no load-bearing, synthetic bone grafts on the market

Download: PDF icon Technology Details (pdf)

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